Human Kidney injury molecule 1,Kim-1 ELISA Kit

Datasheet
  • 中文名称:
    人肾损伤分子1(Kim-1)ELISA Kit
  • 货号:
    CSB-E08807h
  • 规格:
    96T
  • 价格:
    3600
  • 其他:

产品详情

  • 基因名:
    HAVCR1
  • 别名:
    CD365 ELISA Kit; HAVCR 1 ELISA Kit; HAVCR ELISA Kit; HAVcr-1 ELISA Kit; Havcr1 ELISA Kit; Hepatitis A virus cellular receptor 1 ELISA Kit; Kidney injury molecule 1 ELISA Kit; KIM 1 ELISA Kit; KIM-1 ELISA Kit; T cell immunoglobin domain and mucin domain protein 1 ELISA Kit; T cell immunoglobulin mucin family member 1 ELISA Kit; T cell immunoglobulin mucin receptor 1 ELISA Kit; T-cell immunoglobulin and mucin domain-containing protein 1 ELISA Kit; T-cell membrane protein 1 ELISA Kit; TIM ELISA Kit; TIM-1 ELISA Kit; TIM1 ELISA Kit; TIMD 1 ELISA Kit; TIMD-1 ELISA Kit; TIMD1 ELISA Kit; TIMD1_HUMAN ELISA Kit
  • 缩写:
    Kim-1
  • Uniprot No.:
  • 种属:
    Homo sapiens (Human)
  • 样本类型:
    serum, urine, tissue homogenates
  • 检测范围:
    0.312 ng/mL-20 ng/mL
  • 灵敏度:
    0.043 ng/mL
  • 反应时间:
    1-5h
  • 样本体积:
    50-100ul
  • 检测波长:
    450 nm
  • 研究领域:
    Immunology
  • 测定原理:
    quantitative
  • 测定方法:
    Sandwich
  • 精密度:
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 线性度:
    To assess the linearity of the assay, samples were spiked with high concentrations of human Kim-1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
     SampleSerum(n=4)
    1:1Average %89
    Range %82-96
    1:2Average %104
    Range %99-109
    1:4Average %100
    Range %94-106
    1:8Average %92
    Range %85-98
  • 回收率:
    The recovery of human Kim-1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 10296-108
    EDTA plasma (n=4)9084-96
  • 标准曲线:
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    202.409 2.565 2.487 2.317
    101.599 1.518 1.559 1.389
    51.012 1.003 1.008 0.838
    2.50.587 0.578 0.583 0.413
    1.250.433 0.463 0.448 0.278
    0.6250.302 0.304 0.303 0.133
    0.3120.231 0.235 0.233 0.063
    00.174 0.165 0.170  
  • 货期:
    3-5 working days

引用文献

  • Yuan W, et al,Gene,2019
  • Gioulia Romanidou,Nephrology Dialysis Transplantation,2019
  • Hamidreza Badeli,Oxidative Medicine and Cellular Longevity,2019
  • Mohammed Khalid Abood. et al, International Journal of Pharma Sciences and Research,2015
  • Ruili Dang, et al,Eur Neuropsychopharmacol,2015
  • Tekce BK et al,Ann Clin Biochem,2014
  • PETER A MCCULLOUGH et al,Nephrology,2011

靶点详情

  • 功能:
    May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). May play a role in kidney injury and repair.
  • 基因功能参考文献:
    1. neither the inflammatory biomarker calprotectin, nor the tubular biomarkers NGAL and KIM-1, provide robust prognostic information on the loss of renal function in a heterogeneous CKD population. All of them, however, are candidate prognostic biomarkers in primarily inflammatory renal diseases.
    2. High KIM1 expression is associated with Clear Cell Renal Cell Carcinoma.
    3. Human oligodendrocytes undergo apoptosis when exposed to Sema4A and take up H-ferritin for meeting iron requirements and that these functions are mediated via the Tim-1 receptor. H-ferritin can block Sema4A-mediated cytotoxicity. Sema4A is detectable in the CSF of multiple sclerosis patients and HIV-seropositive persons and can induce oligodendrocyte cell death.
    4. Elevated plasma NT-proBNP and KIM-1 in patients with stage 5 chronic kidney disease (CKD5) undergoing maintenance hemodialysis (HD) and HF (+) (heart failure)CKD5-HD patients suggest that natriuretic peptides and KIM-1 may contribute to the pathogenesis of HF in CKD5-HD patients.
    5. These findings suggest that the TIMD4-HAVCR1 variants may be the genetic risk factors for coronary heart disease and ischemic strok
    6. These studies provide evidence that, in the absence of a functional alpha-dystroglycan, TIM-1 mediates the entry of Lassa virus pseudoviral particles through interactions of virions with the IgV PtdSer-binding pocket of TIM-1.
    7. total flavone of Desmodium styracifolium inhibited HK-2 cell apoptosis and autophagy by regulating KIM-1 via p38/MAPK pathway.
    8. Polymorphism +4259A>C in exon 3 of the TIM-3 gene is associated with susceptibility to multiple sclerosis but polymorphism -1637C>T in the promoter region of TIM-1 is not.
    9. High KIM1 expression is associated with decreased proximal tubular epithelial cell function.
    10. findings show that TIM1 is not an essential cellular receptor for hepatitis A virus entry into cultured cells
    11. Urinary excretion of KIM-1 correlates with blood lead levels better than other traditional renal injury biomarkers, including N-acetyl-beta-(D)-glucosaminidase, alpha1-microglobulin, and beta2-microglobulin.
    12. promising results were obtained for circulating KIM-1 prediction of renal outcomes in type 1 diabetes--{REVIEW}
    13. data show that in addition to the phospholipid-binding function of HAVCR1, the enhancement of HCV infection involves other determinants in the IgV domain of HAVCR1. These findings expand the repertoire of molecules that HCV uses for cell entry, adding to the already complex mechanism of HCV infection and pathogenesis.
    14. Review/Meta-analysis: suggest that TIM-1-416G[C single nucleotide polymorphism is associated with the risk of asthma for the Asian ethnicity in the codominant (G/G vs. G/C) and dominant (G/G vs. G/C + C/C) genetic models.
    15. Urinary NGAL is a good predictor of mortality in established pediatric acute kidney injury (AKI) of heterogeneous etiology and outperforms calprotectin and KIM-1. Urinary calprotectin and KIM-1 predict renal replacement therapy requirement in pediatric AKI.
    16. A panel consisting of IGFBP1, KIM1, GCLC and GSTM1 genes could be used in combination for early screening of CKDu, whereas these genes in addition with FN1, IGFBP3 and KLK1 could be used to monitor progression of CKDu. The regulation of these genes has to be studied on larger populations to validate their efficiency for further clinical use.
    17. Quantification of TIM-3 and KIM-1 mRNA expressions, along with KIM-1 protein measurements in urine and blood could be employed as promising tools for noninvasive diagnosis of allograft dysfunction.
    18. Report detection of drug-induced acute kidney injury in humans by combining the sensitivity of urinary KIM-1 along with urinary miR-21, -200c, and -423.
    19. measurement of urinary and renal KIM-1 level may be helpful to evaluate severity of renal pathological damage and prognosis in adult Henoch-Schonlein purpura patients with nephritis
    20. Urine KIM-1 level in acute kidney injury patients was significantly higher than that in the healthy controls.
    21. PCNSL is characterized by frequent Tim-1 expression, and its soluble form in CSF may become a useful biomarker for PCNSL.
    22. TIM-1 is a unique marker for the identification of a human IL-10(+) Breg subpopulation which is partially superimposed with transitional B cells
    23. in the current meta-analysis, based on ten prospective studies involving 29366 participants, we evaluated the role of urinary tubular injury markers (NGAL, KIM-1 and NAG) in predicting clinical outcomes including CKD stage 3, end stage renal disease and mortality.
    24. Urinary KIM-1 levels in the acute kidney injury (AKI) preterm infant group were not significantly higher than in no-AKI group on day of life 1, 3 and 7.
    25. We conclude that KIM-1 might serve as a sensitive biomarker to screen children for kidney damage induced by environmental toxic agents, such as chromium and arsenic
    26. These results suggest that a 6-amino acid deletion polymorphism in the mucin domain of TIM-1 protects from HIV-1 infection with a recessive effect.
    27. The present study shows that serum and urine levels of NGAL and KIM-1 are higher in patients with acute kidney injury than in those without acute kidney injury, and that serum NGAL and the presence of chronic kidney disease are significant predictors of acute kidney injury in scrub typhus.
    28. KIM-1 increases albumin endocytosis in renal tubule epithelial cells.
    29. preliminary data indicates that KIM-1 expression may be associated with stage in Wilms Tumor
    30. Urinary KIM-1 and NAG levels were positively correlated.
    31. TLR2, Tim1, Tim3, TNF-alpha, IgE and EOS play a role in Mycoplasma pneumoniae Pneumonia-related wheezing in children.
    32. The results of our study showed that there is no significant association between TIM-1 5383-5397ins/del and Multiple sclerosis (MS) (P = 0.38); however, the frequency of CT genotype of TIM-3 -1541C>T in patient group was significantly higher than the control group, and there was a significant association between CT genotype and MS
    33. Study emphasizes a strong association of the tubular biomarker KIM-1 with chronic kidney disease progression in chronic heart failure and suggests usefulness as cardiorenal marker.
    34. KIM-1 expression also enhances ERK MAPK activation, and the modulatory effect of KIM-1 on cellular repair process is likely mediated via ERK MAPK signaling pathway.
    35. KIM-1 may mediate high glucose-induced autophagy and apoptosis in renal tubular epithelial cells.
    36. Study suggests that TIM1 -416G>C and -1454G>A single nucleotide polymorphisms are associated with dilated cardiomyopathy susceptibility and prognosis in this Han Chinese population.
    37. elevated baseline plasma KIM-1 strongly associated with risk of early progressive renal decline in type 1 diabetes
    38. Urinary KIM-1 levels increased significantly in patients with contrast-induced nephropathy.
    39. Data show that kidney injury molecule (KIM)-1 and neutrophil gelatinase-associated lipocalin (NGAL), were significantly elevated in welding workers post-exposure.
    40. High NGAL and KIM-1 levels may indicate early diabetic kidney injury; however, we did not observe any relationship between these markers and diabetic indices
    41. Kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin excretion rates correlated with excretion rates of other tubular damage markers and predicted outcome in patients with idiopathic membranous nephropathy
    42. The aim of this review article is to summarize the literature data concerning KIM-1 as a potential novel marker in the early diagnosis and prediction of clinical outcome of certain cardiovascular diseases.
    43. Activation of TIM1 by exposing the cells to TIM4 significantly increased the frequency of apoptotic colon cancer cells. The expression of FasL was increased in the cancer cells after treating by TIM4.
    44. Urine KIM1 level was higher in kidney stone patients before lithotripsy than in healthy controls.
    45. Urinary levels of NGAL are more sensitive than uKIM-1 and uL-FABP levels in predicting renal scarring in vesicoureteral reflux.
    46. TIM-1 ligands increase the amount of cell surface protein, preventing its traffic to the immune synapse
    47. Urinary KIM-1 measured 24 h after the start of drug infusion has the potential to detect early AKI in pediatric patients treated with MTX or platinum-class drugs
    48. Urinary KIM-1 is a significant predictor of death in extremely low-birth-weight neonates.
    49. Urinary KIM1 is significantly higher in patients with clear cell renal carcinoma than in controls. Urinary KIM1 decreases after nephrectomy in clear cell renal carcinoma patients.
    50. decreased serum TIM-1 and TIM-3 levels and association of TIM-3 with nephritis suggest their possible role in the development and pathogenesis of systemic lupus erythematosus.

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  • 亚细胞定位:
    Membrane, Single-pass type I membrane protein
  • 蛋白家族:
    Immunoglobulin superfamily, TIM family
  • 组织特异性:
    Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses.
  • 数据库链接:

    HGNC:

    OMIM:

    KEGG:

    STRING:

    UniGene:



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